CELL 01
90% Clinical Backing
Thiamin (as thiamine hydrochloride)
Thiamine HCl (Vitamin B1)
Label Amount: 6 mg (500% DV) Disclosed Dose
Thiamine is an essential enzymatic co-factor for pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase in the neuronal citric acid cycle. The human central nervous system consumes approximately 20% of whole-body glucose despite representing only 2% of total body mass. Clinical human trials establish that adequate thiamine status is non-negotiable for neuronal energy synthesis, myelin stability, and the presynaptic generation of acetylcholine, the primary neurotransmitter governing working memory and rapid information encoding (Gibson et al. 2013).
Clinical Verdict: Fully disclosed at 6 mg (500% Daily Value); proven biochemical role in neuronal glucose metabolism and acetylcholine neurotransmission.
CELL 02
88% Clinical Backing
Vitamin B6 (as pyridoxine hydrochloride)
Pyridoxine HCl (Vitamin B6)
Label Amount: 8.5 mg (500% DV) Disclosed Dose
Vitamin B6 serves as an indispensable coenzyme in its active pyridoxal 5'-phosphate (PLP) form for aromatic L-amino acid decarboxylase. This rate-limiting enzymatic reaction biosynthesizes dopamine, serotonin, and GABA from dietary amino acids. Furthermore, vitamin B6 acts in the cystathionine beta-synthase pathway to break down homocysteine—an inflammatory vascular byproduct that damages delicate cerebral capillaries and accelerates brain parenchymal atrophy when elevated (Smith et al. 2010).
Clinical Verdict: Fully disclosed at 8.5 mg (500% Daily Value); mandatory enzymatic co-factor for neurotransmitter synthesis and homocysteine clearance.
CELL 03
92% Clinical Backing
Vitamin B12 (as methylcobalamin)
Bioactive Methylcobalamin
Label Amount: 24 mcg (1000% DV) Disclosed Dose
NeuroRecall utilizes methylcobalamin, the pre-methylated, physiologically active coenzyme form of cobalamin, rather than synthetic cyanocobalamin. Methylcobalamin donates methyl groups directly to the remethylation of homocysteine to methionine, facilitating S-adenosylmethionine (SAMe) production and safeguarding the fatty myelin sheaths that insulate cerebral axon terminals. Published clinical investigations demonstrate that methylated B12 optimizes nerve conduction velocity and protects against age-accelerated executive decline (O'Leary et al. 2012).
Clinical Verdict: Fully disclosed at 24 mcg (1000% Daily Value); superior methylated coenzyme supporting axonal myelin maintenance and cognitive longevity.
CELL 04
91% Clinical Backing
Caffeine from Green Coffee (Coffea arabica) Bean Extract
Natural Unroasted Green Coffee Bean Extract
Label Amount: Proprietary Blend (undisclosed fraction of 151 mg) Proprietary Dose
Natural caffeine extracted from green coffee beans acts as a competitive antagonist at central adenosine A1 and A2A receptors, preventing somnogenic adenosine binding and maintaining neuronal firing rates. Unlike anhydrous synthetic caffeine, unroasted green coffee bean extract carries naturally occurring chlorogenic acids that buffer caffeine uptake, promoting sustained alertness, psychomotor speed, and reaction vigilance while reducing the likelihood of abrupt sympathetic nervous spikes (McLellan et al. 2016, Haskell-Ramsay et al. 2018).
Clinical Verdict: Extensive clinical literature backing immediate alertness, attention vigilance, and reaction speed; exact milligram amount masked in the 151 mg blend.
CELL 05
82% Clinical Backing
L-Tyrosine
Free-Form Amino Acid Precursor
Label Amount: Proprietary Blend (undisclosed fraction of 151 mg) Proprietary Dose
L-Tyrosine is the direct precursor amino acid for dopamine, norepinephrine, and epinephrine synthesis. Under sustained cognitive demand, emotional stress, or sleep fragmentation, central catecholamine stores become depleted, manifesting as mental fatigue and executive dysfunction. Human clinical trials (Deijen et al. 1999, Banderet et al. 1989) show that supplemental L-tyrosine selectively replenishes depleted catecholamines, preserving working memory and mental flexibility under acute cognitive stress.
Clinical Verdict: Established physiological support for neurotransmitter replenishment under cognitive stress; standalone studies test 500–2,000 mg, exceeding the entire 151 mg blend.
CELL 06
89% Clinical Backing
Bacopa (Bacopa monnieri) Whole Plant Extract
Standardized Whole Plant Extract (std. to 20% Bacosides)
Label Amount: Proprietary Blend (undisclosed fraction of 151 mg) Proprietary Dose
Bacopa monnieri is an Ayurvedic botanical nootropic evaluated in rigorous double-blind, placebo-controlled human randomized controlled trials (Stough et al. 2001, Calabrese et al. 2008, Morgan et al. 2010). Its active triterpenoid saponins (bacosides A and B) enhance synaptic transmission, protect hippocampal neurons from lipid peroxidation, and stimulate dendritic branching. Clinical outcomes demonstrate statistically significant improvements in higher-order information processing, visual information recall, and verbal learning after 8 to 12 weeks of daily administration.
Clinical Verdict: High-tier RCT human evidence for delayed recall and memory consolidation; standardized to 20% bacosides, but the full 300 mg clinical dose cannot fit within a 151 mg total blend.
CELL 07
79% Clinical Backing
Theacrine
Pure Purine Alkaloid (1,3,7,9-tetramethyluric acid)
Label Amount: Proprietary Blend (undisclosed fraction of 151 mg) Proprietary Dose
Theacrine is a purine alkaloid structurally related to caffeine discovered in Kucha tea (Camellia kucha). Pharmacological trials demonstrate that theacrine modulates both adenosine and dopamine receptors without causing receptor downregulation, meaning it provides sustained mental clarity, energetic drive, and cognitive stamina with substantially less habituation, tolerance development, or cardiovascular heart rate spikes than pure caffeine (Ziegenfuss et al. 2016, Habowski et al. 2014).
Clinical Verdict: Solid clinical pharmacology demonstrating sustained non-habituating alertness; synergizes smoothly with green coffee caffeine, though exact milligrams remain undisclosed.
CELL 08
76% Clinical Backing
Theobromine
Cacao Xanthine Alkaloid (3,7-dimethylxanthine)
Label Amount: Proprietary Blend (undisclosed fraction of 151 mg) Proprietary Dose
Theobromine is a natural dimethylxanthine alkaloid predominantly derived from cacao. While displaying weaker central adenosine antagonism than caffeine, it exerts prominent phosphodiesterase-inhibiting and smooth-muscle relaxing effects. This promotes peripheral and cerebral microvascular vasodilation, increasing blood flow velocity and oxygen delivery to cortical capillary beds without driving sudden spikes in systemic arterial pressure (Baggott et al. 2013, Mitchell et al. 2011).
Clinical Verdict: Clinically supported for cerebral blood flow and smooth stimulant modulation; exact milligram fraction within the 151 mg blend is hidden.
CELL 09
85% Clinical Backing
Rhodiola (Rhodiola rosea) Root Extract
Arctic Root Adaptogen Extract (Rosavins & Salidroside)
Label Amount: Proprietary Blend (undisclosed fraction of 151 mg) Proprietary Dose
Rhodiola rosea is a high-altitude adaptogenic root botanical evaluated across multiple double-blind clinical trials (Darbinyan et al. 2000, Spasov et al. 2000, Olsson et al. 2009). Its active rosavins and salidrosides modulate the hypothalamic-pituitary-adrenal (HPA) axis, attenuating cortisol release and preventing stress-induced depletion of cerebral ATP and neuropeptide Y. Clinical human studies verify marked reductions in intellectual fatigue, enhanced attention endurance during complex tasks, and stabilization of daytime mood.
Clinical Verdict: Robust clinical evidence for stress fatigue resistance and mental endurance; standalone studies employ 100–300 mg, indicating NeuroRecall relies on a micro-dosed botanical complex.
